Sildenafil Citrate

 Sildenafil Citrate

Impotence or erectile dysfunction (ED) has affected over 140 million men all around the world. According to studies, about 50 percent of the male population who have ED are experiencing some kind of physical causes while the rest attributed impotence to psychogenic causes.

Sildenafil Citrate is popular among men with ED. It works by reducing the pressure in your pulmonary artery if you have pulmonary arterial hypertension.

The Truth About Penile Erection

Erection occurs when blood engorged a penis. The penile engorgement happens when the blood vessels increase its delivery of the blood to the penis while the blood vessels that carry blood away from the penis reduce blood removal. For men to achieve normal erection, nitric oxide is produced and released in the penis by way of sexual stimulation.

The enzyme, guanylate cyclase is activated by nitric oxide to produce cyclic guanosine monophosphate (cGMP) which is responsible for penile erection. The cGMP affects the amount of blood delivered and removed by blood vessels from the penis.

Mechanism of Action

Sildenafil Citrate is an effective ED treatment that works by preventing the enzyme, phosphodiesterase-5 (PDE5) from destroying the cGMP, allowing it to accumulate and persists longer which results to prolong penis engorgement.

This prescription drug is rapidly absorbed when taken orally in a fasted state. The plasma concentrations are observed to be achieved within half an hour or an hour and 20 minutes after ingesting the medication. However, the rate of absorption of the drug is reduced when taken with a meal rich in fat.

How to Use the Drug

It is important that you read carefully and understand the patient information leaflet that comes with a package of Sildenafil Citrate. Take this drug orally as instructed by your physician or as needed. Do remember to take this drug an hour or 30 minutes before any sexual activity. It is recommended that the drug be taken once a day.

While being treated with Sildenafil Citrate, make sure you avoid eating grapefruit as well as drinking grapefruit juice, unless otherwise instructed by your physician. The right dosage will largely depend on your response to treatment, medical condition and if you are taking other medications that may interact with Sildenafil Citrate.

Side Effects

There is no association between reduced motility of sperm or sperm count in men and Sildenafil Citrate. Studies of its side effects showed that about 15 percent of users experience one or more side effects.

Some of the most common side effects are

  • stomach pain,
  • facial flushing diarrhea,
  • nasal congestion,
  • dizziness
  • and nausea

If hearing changes happen, discontinue Sildenafil Citrate treatment and see your doctor immediately.